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A 25 HCV GENOTYPES 2 AND 3 : THE PREDOMINANT GENOTYPES AT THE HORIZON 2020 ? J. Delwaide 1 ; , C. Grard 2 ; , D. Vaira 3 ; , B. Bastens 4 ; , B. Servais 5 ; , E. Wain 6 ; , C. Bataille 7 ; , G. Daenen 8 ; , O. Detry 9 ; , A. DeRoover 10 ; , P. Honor 11 ; , M. Meurisse 12 ; , B. Rentier 13 ; , J. Belaiche 14 ; . 1 ; Gastroenterology CHU Sart Tilman ; 2 ; Immuno-Hematology CHU Sart Tilman ; 3 ; Immuno-Hematology CHU Sart Tilman ; 4 ; Gastroenterology St Joseph ; 5 ; Gastroenterology Bois Abbaye ; 6 ; Gastroenterology La Tourelle-Peltzer ; 7 ; Gastroenterology CHR Huy ; 8 ; Gastroenterology CHU Bruyres ; 9 ; Surgery CHU Sart Tilman ; 10 ; Surgery CHU Sart Tilman ; 11 ; Surgery CHU Sart Tilman ; 12 ; Surgery CHU Sart Tilman ; 13 ; Virology CHU Sart Tilman ; 14 ; Gastroenterology CHU Sart Tilman. Currently, genotype 1b is largely the predominant genotype among HCV patients pts ; . Distribution of genotypes, however, is changing with time, with a relative diminution of genotype 1b and 2 and an increase of genotypes 3a, 1a and 4. AIM : To quantify mathematically this evolution and to predict the distribution of genotype in incidental cases in the future. Method : In our data base, genotype and date of the first consultation were known for 1109 pts. The evolution with time of the relative distribution of each genotype year after year from 1992 to 2004 was calculated in incidental cases by using a linear regression model. The determination of the slopes allowed evaluating the evolution of genotype distribution for the future. Results : Global distribution of genotypes was 62 % of genotype 1, 14 % of genotype 3, 12 % of genotype 2, 11 % of genotype 4, 1 % of genotypes 5, a distribution very similar to those observed in the bordering countries. The proportion of incidental cases infected with genotype 1b decreased linearly of about -2.03 % year p 0.0000001 ; . Incidence of genotype 1b in new cases could therefore tend to 0 around 2025. Genotype 1a increased slightly of + 0.75 % year p 0.03 ; . Genotypes 2, 3, 4, did not vary significantly with time during this period. The decreasing slope of genotype 1 1a + and stable slope of genotype 2 and 3 will intersect around 2020. Conclusions : Provided the trends observed during the last decade are confirmed with time, we could anticipate that, in our population, the proportion of new cases with easy-to-treat genotypes 2 and 3 ; will overtake the proportion of new cases with difficult-to-treat genotypes 1a + 1b ; around 2020, for example, buy singulair. Capital Health, Community Health Services HEALTHY SCHOOLS Information and Resources Manual 9.10. 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