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Tropical Medicine, Tokyo Women's Medical University, Tokyo, Japan; Wewak General Hospital, Wewak, Papua New Guinea; School of Medicine & Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea; Department of Medical Zoology, Kagawa Medical University, Kagawa, Japan; Department of Medicine, Karolinska Institutet, Stockholm, Sweden. We conducted three malariometric surveys in East Sepik Province, Papua New Guinea from September 2001 to February 2003 and examined 9500 individuals in ten communities to study the interactions of diversities among malaria parasites, vectors, and humans in different ecological zones. The overall prevalence of malaria parasites was 24%. Positive cases consisted of Plasmodium falciparum 68% ; , P. vivax 27% ; and P. malariae 5% ; . No P. ovale was microscopically observed. Malaria prevalence showed age dependency and highest in 1-9 year age group. We observed significant geographical variations in malaria endemicity between different ecological zones. In wet season, parasite rates of six communities in mountain fringe and plain areas 28-44% ; were generally higher than those of four communities in island and costal areas 13-22% ; . Seasonal variation was remarkable in a fringe community due to striking fluctuation of P. falciparum prevalence. In island and coastal areas, Anopheles farauti was predominant followed by A. koliensis. In mountain fringe areas, however, A. punctulatus was predominant and both A. punctulatus and A. koliensis were found in plain areas. Based on these results, we can differentiate the following eco-epidemiological malaria zones in East Sepik: 1 ; island and costal areas with moderate endemicity, transmitted by A. farauti, 2 ; mountain fringe areas with seasonal epidemics, transmitted by A. punctulatus, 3 ; plain areas with high endemicity, transmitted by A. punctulatus and A. koliensis. 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