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Supplemental Study Results from Vignettes One limitation of cognitive interviewing is that it is difficult to recruit participants who have actually experienced the full variety of circumstances covered in the questions. Also, while many participants' experiences dictate clear "yes" or "no" responses, we are especially interested in how individuals on the "cusp" between the two responses decide to answer. For example, a participant in perfect health and good spirits is almost certain to answer the first question positively, but what about participants who have minor cold symptoms? How do participants decide when their circumstances are sufficient to warrant mention? Some situations are even more complicated e.g., an individual may have had some sexual contact with a drug user, but whether they "had sex"depends on how one defines the term. ; Since it is usually difficult to find such people, we often resort to hypothetical questions such as "what do you consider `have sex' to mean?" These probes are useful, and can highlight a mismatch between respondent interpretations and researcher intentions, but they have limitations. A participant might tell us what she generally thinks "having sex" means, but her thought processes while answering a survey question could be substantially different. Survey response requires additional judgements about the "pragmatic" meaning of the question i.e., what sort of information the researcher is looking for ; . For example, the way that a person conceptualizes "have sex" in a particular question might be different than the way that someone would define it in a more neutral context. An alternative to hypothetical probe questions are vignettes that describe a potentially ambiguous situation; we ask respondents how they think that person should answer the question. The technique is not perfect it is still hypothetical, and does not require the participant to draw on his own autobiographical memory but it does require the participant to go through the process of answering a question using the material in a complex scenario. Six vignettes were written prior to the third round of interviewing describing potentially ambiguous situations relevant to some of the donor history questions. After completing the questionnaire for themselves but before answering any probe questions about their responses ; the eleven participants in this round were told: When you filled out the questionnaire, you answered based about yourself and your own experiences. We would now like to know how you would answer the question for people in a few imaginary situations. We are interested in your interpretation of what the most accurate response would be to these questions under each of these circumstances. 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