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Using a xed concentration of radioligand to label approximately 35 40% of the total [125I]-BOP binding sites, the relative TP receptor density was measured in the smooth muscle layers of human blood vessels with quantitative in vitro receptor autoradiography. TP receptors were present on the endothelial cell layer of all vessels examined and on both the media and the intimal smooth muscle layers when detectable ; of non-diseased and diseased vessels. TP receptor density was signicantly increased P50.05 ; on both muscle layers of atherosclerosis of coronary artery disease and accelerated atherosclerosis of as saphenous vein grafts. Figure 5a, b ; , compared to non-diseased vessels. However, in diseased vessels, fewer TP receptors were localized to the intimal layer compared to the medial smooth muscle layer.
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Introduction: Many patients with end stage renal disease ESRD ; undergoing dialysis therapy suffer from sleep disturbances. Some studies show that nocturnal and daytime sleep abnormalities are accompanied with cardiovascular diseases and adversely affect quality of life-related measures such as general health status, life satisfaction, mood and work performance. On the other hand, inflammatory processes are common in individuals with ESRD and high-sensitive C-reactive protein CRP ; , an inflammatory marker, is predictor of future cardiovascular morbidity. In this study we evaluate the relationship between serum CRP level and the severity of sleep disorders in patients undergoing maintenance hemodialysis. Methods: This analytical cross-sectional study was performed on 158 chronic hemodialysis patients with hemodialysis duration of 6 months ; in autumn 2005. The patients were underwent hemodialysis trice a week. They completed Modified Post Sleep Inventory PSI ; questionnaire to assess sleep related disturbances in 3 sleep levels: bedtime PSI1 ; , nocturnal sleep PSI2 ; and awakening PSI3 ; . Simultaneously, a peripheral blood sample was taken for quantitive high-sensitive CRP level before initiating hemodialysis course. The data were collected, described and analyzed using SPSS v.13 software. Results: The patients were 83 52.5% ; men and 75 47.5% ; women with the mean age of 52.01 SD 16.64 ; years. The mean of serum CRP level was 12.14 SEM 1.53 ; mg l. And the mean of PSI1, PSI2, PSI3 and PSI mean were 3.81 SEM 0.27 ; , 2.93 SEM 0.23 ; , 2.02 SEM 0.16 ; and 2.95 SEM 0.17 ; , respectively. Statistically significant correlation was found between serum CRP level and PSImean rs 0.191 and P 0.016 ; . This correlation was more notable in females rs 0.345 and P 0.002 ; , the ones with hemodialysis duration of 48 months rs 0.364 and P 0.001 ; and the patients with afternoon hemodialytic shift rs 0.255 and P 0.033 ; . Conclusion: This study show that serum CRP level might be correlated with severity of sleep disturbances in hemodialysis patients and it may be some correlation between inflammations and sleep disturbances in these patients that need future studies. Introduction: Erly detection of malnutrition in maintenance hemodialysis MHD ; patients allows appropriate dietary and therapeutic interventions. Nutritional status can be assessed by cheap and widely available methods i.e.laboratory parameters, anthropometry and malnutrition-inflammation score - MIS ; or by more expensive methods requiring dedicated equipment i.e. CT, DEXA ; . MIS is a shrt-term tool to risk-stratify MHD patients. Therefore we compered traditional, subjective techniques of evaluation of body composition i.e. laboratory parameters, anthropometry and MIS ; with objective - DEXA and CT. Methods: 34 non-diabetic patients 14 females and 20 males aged 61.115.1 years ; maintained on chronic hemodialysis were campered to appropriately matched healthy controls. Body composition was assessed by DEXA total body ; , CT abdominal and thigh scan ; . Nutritional status was assesed by laboratory parameters, anthropometry and MIS. Results: HD patients had decreased subscapular skinfold thickness 13.06.3 vs. 23.28.2 cm; p 0.002 ; , lower arm circumference 26.84.4 vs. 29.42.9 cm; p 0.03 ; , decresed total protein 6.40.4 vs. 7.10.4 g dl; p 0.001 ; , albumin 3.80.4 vs.4.50.3 g dl; p 0.001 ; , raised CRP 21.547.8 vs. 2.72.3 ng ml; p 0.047 ; and ferritin 251.8259.8 vs. 71.468.2 ng ml; p 0.049 ; levels in comparison to the control group. In MHD patients DEXA showed statistally significant decreased in legs fat mass 5 671.13 282.2 vs. 9 097.27 862.5 g; p 0.043 ; . Additionally in CT we found decreased fat and muscle area in lower limbs fat area 119.661.0 vs. 142.638.0 mm2; p 0.045; muscle area 229.161.0 vs. 309.843.3 mm2; p 0.001 ; as well as increased intraabdominal fat content 109.346.3 vs. 84.751.9mm2 ; . These parameters corelated with higher MIS values above 7.5 point median of MIS ; . Conclusion: In HD patients MIS malnutrition-inflammation score ; correlate with laboratory parameters, anthrometry and objective methods DEXA and CT ; . References: Kalantar-Zadeh K, Kopple JD, Block G, Humphreys MH. A malnutritioninlammation score is correlated with morbidity and mortality in maintenance hemodialysis patients. J Kidney Dis 2001; 38: 1251-1263, for instance, d3ltasone 10.
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