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However, constant medication may keep the disease under control.

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Pittsburgh post gazette location: the west wing aug 6, 2006 this is the head of state and in my humble opinion to be head of state you must have given some service to the state - what service did mc alesse ever give to and allegra. Primary Use: Multiple Sclerosis Multiple sclerosis MS ; is a progressive disease of the central nervous system. It is an autoimmune disease in which tissues surrounding the nerves of the body are damaged. This results in an inability of the nerves to communicate with one another, and leads to symptoms such as tremor, loss of balance and visual disturbances. MS has no cure. There are four major types of MS: Relapsing-Remitting, Secondary-Progressive, PrimaryProgressive and Progressive-Relapsing. Relapsing-Remitting MS is the most common form, occurring in approximately 75 percent of patients. This type of MS is characterized by intermittent attacks, or relapses, of MS symptoms followed by periods of near-normal functioning. About half of the patients with Relapsing-Remitting MS progress to Secondary-Progressive MS, in which the symptoms of MS may wax and wane, but the disease progresses overall. In contrast, PrimaryProgressive MS patients experience a slow but continuous worsening of MS symptoms without periods of remission. The final type of MS, Progressive-Relapsing, is noted by immediate disease progression with occasional periods of remission. The current market basket of drugs used to treat MS consists of Copaxone and Novantrone as well as the beta-interferons. In 1993, Betaseron was the first beta-interferon approved, followed in 1996 by Avonex and in 2002 by Rebif. All of the beta-interferons are indicated for the treatment of Relapsing-Remitting MS. Avonex is administered as a once-weekly intramuscular injection, while Betaseron is administered every other day and Rebif three times per week. In 1997, Copaxone was introduced to the market. Copaxone is not an interferon but instead works by blocking nervedamaging cells. Novantrone has been on the market for many years as an anti-cancer drug, and in 2000 it received approval for MS. Due to its side effect profile and monitoring requirements, it is typically reserved for more severe cases. Pipeline: Perhaps the most promising compound in the pipeline for MS is AntegrenTM natalizumab ; . Antegren is the first monoclonal antibody being developed for MS; it provides a different mechanism of action than currently available therapies. Because of its unique mechanism of action, Antegren can be used for patients who have not responded to other MS therapies, and it can be used in combination with a currently available treatment. An oral version of Copaxone is under development, but initial studies did not show a treatment benefit. Other drugs in development focus on the immune system and the source of inflammation, but they will not reach the market for a few years.

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